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Studies identified the induction of cytokines, interleukins, and trophic factors predominately involved in neurogenesis, angiogenesis, hematopoiesis, and cardiovascular regeneration being crucial for the mostly paracrine effects [58, 72].
Consistent with the electron microscopy observations, the biochemical assays of LC3 identified the induction of autophagosomes.
We have identified the induction of ZP3 and a hepatic nm23 mRNA as being both sensitive and presumably robust responses.
Our transcriptomic analysis identified the induction of some genes already known to be involved in DNA repair.
Several nonclinical studies of the response to oral antigen have identified the induction of T cells that are associated with, and can adoptively transfer, protection from autoimmune disease (6).
In particular, we identified the induction of the tricarboxylic acid (TCA), α-ketoglutarate dehydrogenase (dihydrolipoamide S-succinyltransferase DLST) (27) or the reS-succinyltransferase DLSTepression of the TCA enzymes oxoglutarate dehydrogenase (OGDH)) and the aconitase 27(ACor athe.5 months of age, as depicted in Figurespiratory
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We could identify the induction of several molecules playing key roles in the regulation of Th1 immune responses, such as CCR2 and CX3CR1 [ 26, 27], which are also important in other autoimmune diseases such as multiple sclerosis [ 28, 29], and CD26, a surface-bound ectopeptidase expressed at high levels on Th1 differentiated T-cells [ 30, 31].
Given the prominent expression of TG6 in the CNS in the developed organism, we were interested to identify whether the induction of TG6 expression correlated with any specific events in development.
Weak homologies to CIB1 were found in rice and Brachypodium in the bHLH domain but no convincing orthologue could be identified (Figure S4) The induction of FT expression is a key step in flowering.
In the context of crosstalk between β-AR signaling and Nor-1 (NR4A3) signaling in skeletal muscle, we have previously identified and examined the induction of Pdk4, Pgc1α, FoxO1, and Lipin1α over following acute β-AR activation [ 28, 36].
Gomes-Alves et al. [ 38] used 2-DE to compare protein profiles of cell lines expressing wild-type or F508del- CFTR at 37°C and 26°C, and have identified mechanisms, including the induction of the unfolded protein response and downregulation of degradative proteins, which may contribute to the cold-shock-induced rescue of F508del- CFTR.
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