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Data analysis disclosed large numbers of DEGs between NS, AKs and tumor samples and identified the activation of several known oncogenic pathways in SCC, some of which were also activated in AKs.
Here, we identified the activation of the eEF-2 kinase-mediated autophagy as a new mechanism responsible for the insensitivity of cancer cells to growth factor inhibition.
As we have identified the activation of AMPK in monocytes, this may contribute to reduce visceral adiposity.
For assessment of apoptosis, we identified the activation of caspase-3, which is the common final executioner caspase for the apoptotic pathways.
Indeed, we identified the activation of ER stress signaling pathways that are affected at transcriptional, post-transcriptional and post-translational levels.
In response to nCB, but not PEG-nCB, reverse phase protein array (RPPA) identified the activation of several DNA damage (e.g., PARP, p-Chk2, p-ATM) and MAPK/Erk (p-ERK, p-MEK1/2 -response p-MEK1/2 -response
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Moreover, our work identifies the activation of the Cdk5 signalling pathway as a potential mechanism underlying the deactivation of contralateral PL excitatory neurons, which suggests that Cdk5 acts as a key negative regulator of neuronal excitability in the PL.
Activation of NFAT by TRPC6 mutants was blocked by inhibitors of calcineurin, calmodulin-dependent kinase II, and phosphatidylinositol 3-kinase thus identifying the activation of the calcineurin-NFAT pathway as a potential mediator of FSGS.
IPA Canonical Pathways Analysis was performed to identify the activation of pathways from a library of canonical pathways.
The lists of transcripts altered ≥ 2-fold at each time point were imported into IPA to identify the activation of tight junction signaling pathways.
Upstream Regulator Analysis in IPA was performed to identify the activation of upstream transcriptional regulators that could explain the observed gene expression changes.
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