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Loss of function tumor suppressor lines have been identified that result in solid tumors at varying frequencies [30], [31], [32].
Subsequently, 187 mutations have been identified that result in cMyBP-C cardiomyopathies.
Approximately 90 haemoglobinopathies have been identified that result in abnormally high oxygen affinity.
Several specific loci have been identified that result in PD, including mutations in the PARK 1 to PARK 8 genes, although these forms of PD are rare and usually display atypical features of the disease (Foltynie et al. 2002).
A few rare and polymorphic variants in ion channel genes have been identified that result in changes to channel properties consistent with an increased predisposition to seizures [ 8, 10].
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Combination therapies were identified that resulted in complete and sustained tumor suppression in vivo.
Within the DoE the conditions of plasma treatment were identified that resulted in selected optimal values of θW, γSp and O/C responses.
Considering applications to thermal desalination and concentrated solar thermal power generation, optimal design configuration of waveguide concentrator-receiver system is identified that results in the least levelized cost of power (LCOP).
Optimal mutations in the primary and secondary protease cleavage sites of the env gene were identified that resulted in the stable secretion of a trimeric Env glycoprotein in mammalian cell cultures.
A distinct methylation pattern was identified, that resulted in reduced mRNA expression in all cases.
A mutation in murine EpoR, R129C, was identified that results in EpoR dimerization and constitutive activation.
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