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Seventeen cases were viremic (genotype 3 HEV), two had identical HEV sequences but no identified relation.
Also, because vitamin D status and A1C levels change with age and an association may be obscured by treatment for diabetes, a secondary objective was to examine whether any identified relation varies with age and/or diabetes history.
Furthermore, roles of Helicobacter pylori infection in autoimmune diseases were discussed (38) providing a reasoning for the identified relation of the GWAS-trait ' Helicobacter pylori serologic status' the KEGG-pathway 'Rheumatoid arthritis'.
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Visualizing identified relations allowed capturing genes and gene clusters that are related to single or multiple phenotypes, which are described below.
The Random Forest algorithm generates useful classification-related information, which allows in-depth analysis and better visualization of identified relations.
The problem with this approach is that the identified relations are non-specific and that the severity of the disease is not strongly correlated with the measured values.
Residuals, calculated as deviations from the identified relations and normalized with the model uncertainties, are analyzed on-line with incremental/decremental statistical techniques.
We divided identified relations into three groups: (i) incorrect relations, (ii) confirming previous observations and (iii) novel relations.
As expected, the results obtained using automatically identified relations are significantly lower than those obtained using gold-standard temporal relations.
We tried different visualization techniques such as graph and tree structures for enhanced visualization of identified relations.
In visualizing identified relations to a phenotype, occurrence information of a feature in strains of a particular phenotype is integrated with the phenotype importance (see next section).
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