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This connectivity was dramatically improved by incorporating the components of the 13 identified pathways within the network.
Upon identification of such pathways, we performed more in-depth analysis to characterize the identified pathways using coincidence imaging and time-resolved studies.
The identified pathways and genes, particularly Chmp7, may therefore represent attractive molecular targets for development of a therapeutic approach for SBMA.
New functional profiling methods24 identified pathways required for microbial colonization of the human body, differentiating those enriched for the human habitat from those universal to microbial life.
Importantly, our findings suggest that the identified pathways and genes, in particular Chmp7, may serve as potential therapeutic targets in SBMA.
Interestingly, many of the identified pathways were associated with axonal branching as well as neuromuscular junction formation and maintenance (focal adhesion, extracellular matrix, integrins, ErbB, endocytosis and WNT signalling).
"Our study identified pathways that can be modulated in MS and we are working on tools for this.
Other identified pathways are related to ion and electrolyte transport.
Some of these identified pathways may become potential therapeutic targets for a new generation of drugs.
Interestingly, we found that the identified pathways have roles in development and differentiation of ES cells.
Interestingly, 13 out of the 51 identified pathways are known mediators of toxicity and cell death.
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