Two distinct and mutually exclusive H3.3 mutations (K27M and G34R/V) have been identified in paediatric GBMs14,15, associated with global downregulation of the repressive histone mark H3K27me3, DNA hypomethylation16,17,18, ALT (Alternative Lengthening of Telomere) phenotype14 and upregulation of the MYCN pathway19.
From October 2010 to February 2011 a cluster of HEV-associated meningitis cases was identified in paediatric patients who had presented at two large tertiary hospitals in Pretoria in the Tshwane Metropolitan Area, Gauteng, South Africa (SA).
The authors identified New Paediatric Clone isolates (spa type t105 or t777) in France, and very sporadically in Australia and Germany, as well as PVL-positive CC5-MRSA-VI (spa t311) in Switzerland.
GATA2 mutation has also been identified in paediatric neutropenia and aplastic anaemia (Pasquet et al, 2013).
The trauma registry identified 162 paediatric motocross trauma patients over an 11-year period, with 30 (18.5%) of these injuries to the chest and/or abdomen.
This review identified 8 paediatric studies using current validated methods of scintigraphy or 13C-OABT in both healthy children, those with neuro-disabilities and reflux.
Using our nation-wide database, we identified that paediatric head CT scanning is associated significantly with the subsequent risk of benign brain tumour, observing a 2.97-fold higher risk in the exposed cohort compared with the unexposed cohort.
An analysis of suicide-related events identified in paediatric randomised controlled double-blind ADHD clinical studies involving both atomoxetine and methylphenidate undertaken by Eli Lilly (studies HFBD, HFBK, LYAV, LYBI and LYBR) was conducted [ 19- 22].
The approaches used to identify candidate paediatric conditions and develop clinical indicators are specific to the Australian healthcare setting for the years 2012 and 2013.
There are three key components for this study protocol: to identify candidate paediatric conditions, to develop clinical indicators for these conditions and to evaluate the wiki methodology.
