Nonspecific digestion is usually avoided, especially when identifying on large databases, because of its running time and high memory demand.
With this approach different cDNAs can be identified on a large scale basis within a cDNA library.
In total, 19 IS 711 elements were identified on the large chromosome and 12 on the small chromosome of B. pinnipedialis.
In total, 606 candidate resistance genes including 302 primarily identified overlapping genes, 184 additional rescued genes, and 122 VP1620-specific genes, were identified on a large scale and functionally classified into diverse defense-related pathways.
An additional six genomic islands were identified on the large plasmid (PI-1 to PI-6 in Figure 3) (see Additional File 4, Table S2 for full list of plasmid islands and gene content analysis).
Fadista et al. [ 36] reported CNV distribution in cattle to reflect chromosomal size with the most CNVs being identified on the largest chromosomes.
A rather different type of physical network was constructed by Collins et al. [ 45], who combined two independent screens carried out by Gavin et al. [ 46] and Krogan et al. [ 47], in which CCA links were identified on a large-scale using affinity-purification followed by mass spectrometry (AP/MS-Combined).
Protein purification [ 3][ 4] Computational structure modeling [ 3] Transcription assay, Nucleosome fate and DNase I footprinting [ 3, 5] In structural modeling, three negatively charged surfaces (regions 1, 2, 3) were identified on Rpb1, a large subunit of yeast Pol II, and plausibly interacted to histone octamer, especially H2B N-tail region, by the electrostatic force.
The subset of breast cancers that are CK5/14-positive is enriched for the so-called basal-like tumors, identified on the basis of large scale gene expression patterns [ 5- 9].
