Taken together, holistic approach to identify possible interacting genes and SNPs with CANGES provides a means to rapidly identify networks for any set of genes and generate novel hypotheses.
Figure 5(A) shows the best case of identified network topology for SIM (precision : 0.33, recall : 1.0).
Using a composite ranking system, we identified network modules most relevant for 15 independent phenotypic categories, highlighting a mitochondria/synaptic module that links sleep and stress.
Interestingly, the highest-ranked identified network was highly enriched for cancer, with an emphasis on tumorigenic processes.
IPA computes a score for each identified network.
Stated differently, the identified neural network accounted for about 97% of the relationship between intellectual enrichment and cognitive status, suggesting little to no unique contribution of intellectual enrichment to cognitive status over-and-above the identified network.
The identified networks showed enrichment for various canonical pathways, including NFκB and IL-8 signaling.
The threshold value of betweenness centrality lies between 55 and 190 for the identified networks.
(See Additional file 4 for all identified networks and their respective molecules).
We hypothesized that the patterns by which high frequency activity is propagated would help elucidate epileptogenic networks and thereby identify network nodes relevant for surgical planning.
