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A previous structure activity relationship identified modifications to the base moiety of adenosine (Ado) that result in substrate and inhibitor activity.
DNA methylation and histone modifications are the most identified modifications that selectively activate or inactivate genes that control cell growth, proliferation, and apoptosis.
We identified modifications in the expression patterns of these genes that could account for developmental differences between P. patens tip-growing cells and A. thaliana pollen tubes and root hairs.
The set of identified modifications was then analyzed together in Step III: analysis of combined modifications.
This work identified modifications of glycolysis and alanine synthesis pathways in pre-tumor stages.
However, our data also identified modifications at the levels of proteins involved in apoptosis regulation, namely the Bcl-2 family members.
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As expected, this newly identified modification of IRF3 is not needed for its transcriptional activity (Chattopadhyay et al., 2016).
In order to evaluate the distribution of acetylation sites in the acetylated proteins of Y. lipolytica, we calculated the numbers of identified modification sites per protein.
Based on these data each of the identified modification patterns is assigned a position index (Supplementary Table S1) in order to build the full depth-wise modification profile.
Histone modifications are most complex, as those occur at multiple sites within multiple genes, blurring assessment of biological impact of identified modification [ 54].
In the same data set, we recently identified modification by stress in the relation between bone lead and heart rate variability (Clougherty JE, Peters JL, Schwartz J, Kubzansky L, unpublished data).
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