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The study was also included in two of the identified meta-analyses [44, 62].
BMS identified Meta-Family C as the most likely family (exceedance probability = 0.96) (Fig. 3 A ).
Predetermined inclusion criteria were applied to each identified meta-analysis independently by two authors.
The analyses were based on the total number of participants per trial arm, as reported in the identified meta-analyses.
None of the identified meta-analyses describe the association between physical activity and vascular events by age.
The search focused on clinical trials, relevant sub-studies of clinical trials identified, meta-analyses and systematic reviews.
We then extracted the relevant data on relative risk estimates for each newly identified meta-analysis as outlined above.
Owing to the considerable heterogeneity between the studies identified, meta-analysis, as proposed in our original protocol, was not appropriate.
If two or more eligible RCTs are identified, meta-analyses will be performed with Review Manager 5.3.
With knowledge gathered by in-depth analysis, a detailed regulatory network was set up by joining newly identified meta-genes with related transcriptional factors.
Our meta-analysis approach re-analyzed four EBV-related tumor data sets and identified meta-genes using expression profiling and integrated bioinformatics.
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