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The results lent support to research that identified locus of control as instrumental in treatment outcomes and headache-related disability [23, 25, 26, 32, 33].
Furthermore, the identified locus represents highly conserved sequence and contains multiple known transcription factor binding sites for HNF1α and β, SP1, HNF6, and GATA6 [50].
The newly identified locus on chromosome 6 (berghei resistance locus 6, berr6) consists of only two genes and is thus much smaller than those identified with standard crosses.
In agreement with the nomenclature of previously identified QTLs [17], [18], we termed this newly identified locus on chromosome 6 berghei resistance loci 6 (berr6).
In annotating predicted loci as sharing conserved synteny with known ncRNA-encoding loci, homology and conserved orientation relative to EITHER the nearest upstream OR nearest downstream gene of the previously identified locus was regarded as sufficient.
Subsequently, a heuristic automated program proposed by Fouts 2006 [36] for prophage detection enables multiple curation of identified prophage locus by comparison with HMMs of phage proteins and further facilitates sub classification of the identified locus.
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Finally, we identified loci that explain a significant amount of heritability across multiple traits.
The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits.
The rest 230 were newly identified loci among which 159 were highly probable loci.
We identified 14 putative loci from individuals from Easter Island and Guam, and most matched previously identified loci of individuals of C. miliaris from American Samoa [10].
We identified locus-specific methylation differences between DCIS and matched adjacent-normal tissue (95,609 CpGs, Q < 0.05).
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