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Previous studies have identified linkage of the 5q31 locus and/or association of specific variants in this region with several other diseases, including CD and asthma/allergic disorders (23– 23).
Genome-wide QTL analysis identified linkage of the number of epithelial voids to two loci, one on chromosome 7 (Fig. 5E), centered on the rs31944466 SNP located at 31 cM (Fig. 5F), and one on chromosome 14, centered on the rs30160834 SNP located at 61.4 cM (Fig. 5G).
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Linkage data were merged with cytogenetic mapping data to confirm the order of markers or to identify linkage of isolated or weakly informative markers.
Recombination may actually be promoted between the HD genes, which could explain previously identified linkage map distances of 16 cM for the genomic region containing MAT A (Raper 1966).
In addition, we identified linkage between RNA splicing of exons 5 and 6, and splicing of exon 5 only and exons 4, 5, and 6 in FACS-purified CD4+ and CD8+ thymocytes.
Conclusions: Overall, the review of the existing literature identified linkages between several of the environmental exposures and type 2 diabetes.
Such a high expected prevalence of Addison's greatly increases the power of identifying linkage by facilitating the detection of segregating markers in a genome-wide scan.
STRs have been used successfully to identify linkage disequilibrium between pairs of loci, such as CD4 [ 44] and G6PD [ 45].
We used the IPA tool to identify linkages between putative targets of de-regulated miRNAs and differentially expressed genes in mouse scrapie [44], [45].
Childbirth hospitalizations were identified by linkage of the hospital separation data with birth data.
Design Population based cohort study of general practice patients identified by linkage of nationwide registries at the individual level.
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