Sentence examples for identified lifespan from inspiring English sources
To elucidate whether the above identified lifespan extending herbs regulate a specific stress response gene, we used the transgenic C. elegans (CL2070) expressing GFP as a reporter for inducible hsp-16.2 expression.
An example of an integrated approach to identify lifespan regulating loci is represented by testing whether genetic variants associated with potential biomarkers also associate with longevity.
On the basis of statistical analyses, the standard model to identify lifespan QTLs explaining the phenotypic variance in the F2 generation included maximum body weight as covariate in the first QTL scan and did not include covariates in the second QTL scan.
This observation is consistent with the sex-specific effects of identified QTLs for lifespan [32] and complementation data for other candidate genes for aging [33].
A growing number of genes and signaling pathways are being identified that determine lifespan in Caenorhabditis elegans (Lapierre & Hansen, 2012).
Several mutated genes have been identified to extend lifespan by large-scale RNAi longevity screens in C. elegans [ 2].
Numerous genes have been identified that modulate lifespan, but the influence of natural variation in aging has not been well studied.
Thus, in contrast to adolescent and adult OCD, pediatric (preadolescence) OCD may be associated with decreased frontostriatal activity, a recognized endophenotypic marker for ADHD that has been consistently identified across the lifespan.
In addition to miRNA mutants that showed an extended lifespan, we identified miRNA mutants that had shortened lifespans.
Translocation of DAF-16 to the nucleus and subsequent activation is required for increased lifespan due to reduced IIS, and many DAF-16 target genes have been identified as modulators of lifespan (Lin et al., 1997; Ogg et al., 1997).
At least 10 gene mutations have been identified that extend the lifespan of mice by up to half, and in humans several genetic variants have been linked with longevity.
