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These aims are not theoretical: they have been translated into specific action points with target dates and identified lead officers.
The design of these compounds is based on a recently identified lead compound from a high throughput screen.
The challenges identified lead us to the conclusion that while maps can be tremendously helpful, they should be used carefully.
By conducting a virtual screening of 50,000 known inorganic compounds, we have identified lead titanate (PbTiO3), a perovskite, as the most promising photocathode material.
Among several strategies, depending on the chemical structure of the identified lead, the introduction of conformational restriction and/or steric hindrance are popular tactics in medicinal chemistry.
The identified lead compound showed IC50 value of 6 μm for HDACs, found to induce G1 cell cycle arrest at significantly low concentration (1 μM) and caused significant loss in mitochondrial membrane potential at 5 and 10 μM.
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Its roots go back to 1998, when Ron Motley, a South Carolina lawyer and veteran of the tobacco settlements, met state attorneys-general and identified lead-based paint as a promising area for public litigation.
The American, who was not identified, led a group working in Mauritania.
In June, the investigation in which Boubaker was identified led to the arrest of a dozen people in nine locations north of Paris on suspicion of terrorist-related activities.
The issues we identified led to a meaningful discussion of the political, financial, social and intercultural context that they are entrapped in.
The association analysis provided in this study has identified leads for future analysis.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com