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An investigation by Goldstein et al. [ 37] of proteins that co-precipitate with F508del- CFTR has identified interaction with valosin-containing protein (VCP /p9, a component of the translocation machinery, as being associated with inefficient processing of the mutant CFTR.
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Yet, only a few competency frameworks identified interactions with youth as a competency area.
As expected, we identified interactions with genes involved in transcription and chromatin modification.
We identified interactions with falafel, a component of the PP4A complex and homologue of C. elegans smk-1 (33).
Previously, we had identified interactions with mago-nashi and Y14/tsunagi, two components of the RNA-binding exon junction complex (EJC) (20).
In addition, the interaction network generated using literature specific to skin through Ingenuity Pathway Analysis (IPA) identified interactions with genes that are key regulators of normal wound healing and are altered in non-healing skin.
Similarly, a small overlap of the experimentally identified interactions with the previously predicted interactions of Geisler-Lee et al. [ 45] and Cui et al. [ 46] is observed (see Fig. 3; Additional file 8, panel A2).
Functional involvement of GDNF family ligands has not been previously reported in ER-MC and the identified interactions with TWIST1 provide a novel therapeutic opportunity for this MC subtype.
LASSO regression, SPCA and BMA have high interaction detection rates as assessed by the percentage of correct identification of the interaction term, while DSA algorithm barely identifies interaction with a very low rate of 4.4%.
In this short review, we summarize recent findings identifying interactions with other proteins – directly or through membrane lipids – and briefly discuss how these observations can provide clues to the design of better therapeutic approaches.
After copying and pasting the locus IDs of the 10 PRX rice proteins into the RIV query box, we were able to identify interactions with 161 proteins that were mediated by four of those PRX proteins (Fig. 6).
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CEO of Professional Science Editing for Scientists @ prosciediting.com