Overall, the network modulations identified in the beta and gamma frequency bands differed widely, both regarding functional effect (increase or decrease), and network connections.
The frequency of maternal microchimerism (XX chromosomes) identified in pancreatic beta cells of non-diabetic male children has previously been reported to be approximately 0.5% [ 26, 27] and this could have contributed to the higher percentage of insulin-positive cells with an opposite complement of sex chromosomes in male recipients reported here.
These changes to the females' internal environment could lead to alterations in pregnancy parameters (hormone levels, placental function, blood flow) (15, 42, 43) and consequently affect development of the F2 offspring, contributing to the changes we have identified in F2 BETA offspring.
Our initial list of novel transcripts included 73% of the lncRNAs identified in purified mouse beta cells [ 20] and 54% of the lncRNAs identified from total mouse islets [ 15].
The LC-MS/MS result indicated that glycosyl hydrolase (gi|159121974) was identified in band c3, beta-1,6-glucanase (gi|66845136) was observed in band f3, however no relative proteins were identified in band e3.
Sequences not identified in the alpha and beta group were compared further against nucleic acid coding sequences (delta) and finally the whole nucleotide database (zeta).
YxxO motifs and proline rich sequence stretches near the C-terminus, which are conserved among all HAdV and may be part of a protein interacting domain [ 39], were identified in the predicted RID beta protein of HAdV-A31.
Representatives of most K channel families have been identified in pancreatic islets, and specifically in beta cells.
A bursting pattern similar to that in this study, in which spiking was also initiated smoothly from the silent hyperpolarized phase and terminated in depolarization block, was previously identified in a model of pancreatic beta cell activity [46].
A total of 943 proteins were identified in liver, brain, alpha and beta cells.
