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As the exact mechanisms by which the smoking affect the pathogenesis of GS have not been identified, further studies are required to identify the effect of smoking on GS pathogenesis.
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With an increasing number of both inherited and acquired mutations in DDX41 gene being identified, further study of how DDX41 mutations lead to hematologic malignancies is needed.
The reference lists of eligible articles and related reviews were also screened to identify further studies.
However, their reference lists were screened to identify further studies for inclusion.
Finally, the lead or contact authors of all identified studies were asked to identify further studies.
Experts were contacted to identify further studies.
We also surveyed all UK Clinical Trials Units to identify further studies.
Contact with experts did not identify further studies.
Relevant researchers were contacted, and reference lists reviewed to identify further studies.
Their bibliographies as well as relevant literature reviews were rigorously checked to identify further studies.
In addition, we searched the reference lists of retrieved articles to identify further studies.
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