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That report also identified functional effects of the IL-4R polymorphism pertinent to Th1 and Th2 cells.
STAT3 gene polymorphisms were reviewed based on previously published literature which identified functional effects or associations with disease.
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These identify functional effects, but may fail to correctly distinguish direct from indirect targets (Wagner et al., 2001).
Here, the study of splicing quantitative trait loci (sQTLs) through the statistical testing of genetic association with changes in alternative splicing proves useful in identifying functional effects that may contribute to the etiology of various genetic diseases.
To identify functional downstream effects of the region of rs7021880, a database and literature search of transcription studies was performed.
To identify functional downstream effects of C5-TRAF1, a search was performed in publically available databases and datasets [ 21- 26].
These findings indicate that detection of urinary porphyrin alteration may be a method for identifying functional early effects of environmental chemicals (Ng et al. 2005).
In this study, we have identified functional homologs of the CHD family members in Ae. aegypti and looked at the effect of Wolbachia infection on their expression.
Experimental studies have identified different functional effects of stromal PDGF receptor signaling in various tumor models.
In general when missense mutations are identified, their functional effects are tested on recombinant proteins produced either in E. coli or mammalian cell culture systems.
It is a difficult challenge to identify the functional effects of protein acetylation in specific pathways.
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