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We report the SAs identified for liver and kidney toxicity.
A/J mice demonstrated the highest steatohepatitis and gene loci were identified on four chromosomes, particularly chromosomes 2 and 15 in regions that had previously been identified for liver fibrosis [ 71].
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Patients with a poor prognosis are usually identified for likely liver transplantation.
There are 69 gene targets identified for potential liver-selective expression, and the priority score ranges from 1.64 to 5.88 (see Additional file 2).
Those infants who remained on PN prior to discharge with insufficient laboratory follow up (sufficient laboratory follow-up defined as having laboratory data available for at least four weeks post PN cessation), those with other identified etiologies for liver disease, and those with cyanotic congenital heart disease were all excluded from this study.
87 Several mechanistic targets have been identified for metformin in the liver, 88 including stimulation of the postreceptor protein, IRS-2.
Many of the associations identified for reactions affecting the liver and skin involve human leukocyte antigen (HLA) genes and for reactions relating to the drugs abacavir and carbamazepine, HLA genotyping is now in routine use prior to drug prescription.
Phenols (Table 1, SA ID = 6) were identified as hepatotoxic by a recent study [21] that used a dataset of pharmaceutical chemicals as starting point to identify SAs for liver toxicity.
Cohort studies of excess body weight and risk of liver cancer were identified for a meta-analysis by searching MEDLINE and EMBASE databases from 1966 to June 2007 and the reference lists of retrieved articles.
A zoonotic source of HEV infection was identified for 3 of these patients: pig liver for patient 4, pig meat for patient 6, and wild boar meat for patient 7. Prothrombin time, a surrogate marker of hepatic insufficiency, averaged 63.9% (± 29.1%) of the reference range among the 8 HEV genotype 3 infected patients.
Footprints were identified for many genes with known roles in liver growth.
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