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For example, a randomized trial of just 100 patients could lead to the termination of development of 90% of inactive agents whereas at least 80% of agents with a meaningful and realistic increase in progression-free survival would be identified for confirmatory study.
The total number of presumptive events identified for confirmatory review across all sites was 765.
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We believe, however, that reagent strip testing remains a valuable tool for identifying people for further confirmatory testing by microscopy of urine in screening programmes handling large numbers of patients in a short period.
We identified confirmatory evidence supporting an eQTL within intron 19 of CLEC16A for DEXI expression within the supplementary information of two further, recent independent data sets (18, 19).
Hence, it can be inferred that PTEN protein IHC if used to identify patients requiring confirmatory gene mutational analysis for CS will result in a high level of false positives and, clinically, is not useful for the identification of patients at risk of CS. (2) Confirmatory Gene Mutational Analysis.
An IMMPACT consensus meeting was therefore convened to identify the critical research design considerations for confirmatory chronic pain trials and to make recommendations for their conduct.
If the combined block was positive, the patient was scheduled to return for confirmatory blocks to identify which structure was responsible for the effect.
Colonies will be identified according to manufacturers' recommendations and subcultured for confirmatory testing.
In mutation scanning methodologies such as SSCP and DHPLC, samples demonstrating variant profiles are selected for confirmatory analysis with mutation identifying methods such as dideoxy sequencing.
Examining consistency of effect across multiple clinical endpoints in a proof-of-concept study may identify efficacious therapies and enable dose selection for confirmatory trials.
For confirmatory analyses, a second sample was identified.
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