No outliers were identified for changes in lower and upper body muscular strength.
Statistically significant outliers (p < 0.05) were identified for changes in body weight [ 61, 66], fat mass [ 69], percent body fat [ 69], and VO2max in mL·kg−1·min−1 [ 72].
Unlike FEV1, a generally accepted minimal clinically important difference has not yet been identified for changes of IC following a therapeutic intervention, even though an increase of 100 mL can be considered to be potentially clinically meaningful [ 27].
Three candidate baseline correlates were identified for fold-change in HAI titer.
Two candidate baseline correlates were identified for fold-change in percentage of flu-specific CD8 T-cells.
Nevertheless, 1397 genes (Additional file 9) could be identified for which changes in gene expression levels were specific for Pkd1 -/- kidneys.
QTLs were also identified for mechanically induced changes in stiffness, median stress values and skewness of stress distributions.
Indeed, this would explain why over half of the mutations identified for PrDs involve changes in charge (Rossetti et al., 2011; Shen and Ji, 2011).
In addition, five challenges for this science are identified: accounting for change, addressing sponsorship and timelines, appreciating different knowledge systems, adaptively communicating, and improving linkages to policy.
In a multiple case analysis, Bosch et al. (2007) suggested that there is often a mismatch between identified barriers for change and the implementation interventions chosen [ 27].
