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The graphical genotypes feature of JoinMap identified doubtful double recombinants, which were reevaluated by inspection of stacked sequences and corrected as needed; for example, some genotypes that the software called homozygotes were clearly heterozygotes with minor allele reads below threshold.
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Frequently, the radiologist reporting CXR identifies doubtful or equivocal findings that could be referred to as both pulmonary and extra-pulmonary lesions or also as pulmonary pseudolesions because of different planes overlapping or composite areas of increased opacity.
This would include those who had solitary metastases identified or doubtful CT images (Fig. 4).
Polymorphisms in which the identified base is doubtful due to a high error probability in the trace file, and therefore the most probable cause of the observed variation, are filtered out [ 29- 31].
Although the overall evaluation of the instrument was satisfactory, specific doubtful items were identified.
When considering TBEV.EDIII beads only, 61 sera were found to be positive and 13 negative, while ELISA identified 59 positive and three doubtful results and TBEV MNTs found 62 positive results (Table 4).
Contrary to what has been observed in this work, Asuretuli Shavi, a black berried female variety from the Southern Georgia (Marneuli district), was identified as a case of doubtful Georgian origin, because of based on SSR genotyping it showed a PO relationship with the ancient Greek variety Rhoditis [ 12].
In the case of doubtful pathogenicity of the identified variants, the same procedure as described above for the COL1A1 and COL1A2 genes should be followed.
One hundred and forty-seven substances have been excluded from the evaluation during the process as they were identified as double entries, mixtures or of doubtful relevance.
Doubtful tight double recombinants were identified using the CHROMPIC option of CRI-MAP and responsible erroneous genotypes were corrected when present.
Central monitoring subsequently identified 14 enroled patients whose eligibility criteria were doubtful.
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