Sentence examples for identified doses from inspiring English sources

An iterative process identified doses that minimized a weighted combination of objective functions related to the posterior distributions of PK/PD parameters stemming from the Bayesian analysis.

However, further calibration and validation of identified dose are warranted to explore more dose-response toxicity assessment and their kinetics of in vivo distribution.

CPZ equivalent doses were the identified dose ratios of each antipsychotic in relation to 100 mg of CPZ.

For children< 6 years the identified dose was higher than the one for neonates and children> 6 years [ 48].

Heterogeneity was assessed by χ tests and quantified by I. Meta-regression models identified dose threshold and independent predictors of effects.

For all the chemicals selected and target sites for disruption that were identified, dose-response characterization results and/or relevant low-dose research evidence were reviewed and categorized using the criteria mentioned in the Materials and methods.

The first Phase I trial of carboplatin was completed in 1981 and this identified dose-limiting haematological toxicity, as well as early signs of activity, but failed to detect any significant renal side effects (Calvert et al, 1982).

Both the PIR (isotonic) and SAM (linear) penalized regression methods identified dose-dependent increases and decreases in mRNA expression in the frontal cortex 6 h after an acute, oral exposure to both deltamethrin and permethrin.

Despite preclinical evidence suggesting a synergistic interaction between ketamine and opioids promoting analgesia, several clinical trials have not identified dosing regimens capable of eliciting a benefit in the co-administration of ketamine with opioids.

The first step in clinical trials will be to identify doses of therapeutic agents that reverse these biomarkers of disease to assist in design of much longer trials with functional and anatomic endpoints.

Preliminary dose-finding experiments were carried out to identify doses of candesartan and aliskiren that result in a systolic blood pressure (SBP) of 150 or 130 mmHg after 5 days of treatment.