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Genetic and clinical association studies have identified disrupted in schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness.
Our previous work identified disrupted cilia in talpid mutants (Brugmann et al., 2010).
For example, publications based on TCGA data have identified disrupted pathways in many cancer types, and these studies attempt to integrate sequence data, expression data, epigenetic data and copy-number data to get a wholistic view of the cancer genome [ 12- 14].
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DACT1 has been identified disrupting the expression and localization of β-catenin, thus dysregulating Wnt/β-catenin signaling in NSCLC [ 13].
To study the neighborhood of the candidate genes in order to identify disrupted expression modules in the distance network, we had to bound the neighborhood to a limited size because the network was very densely connected, and thus the neighborhood of a candidate gene consisted of almost all genes in the network.
We performed both GSEA aimed at identifying disrupted signaling pathways as well as analyses to identify individual, differentially expressed genes between spt and wild-type tissue.
Mobile elements (insertion sequences and miniature inverted repeat transposable elements) have been mapped to the chromosome to identify disrupted genes (40).
The extraction and robust quantification of bacterial protein signals is also a way to identify disrupted protein networks that drive onset and perpetuation of CD and, therefore, candidate targets for IBD treatment based on gut-ecological intervention strategies.
Therefore, although the use of these pathway databases as prior knowledge helps to define and identify disrupted pathways, it is possible that there are many more gene modules as yet undescribed that contribute to cancer.
In particular, a recent study (Finn et al. 2013) used an unbiased whole-brain parcellation method which allows identifying disrupted connectivity networks fMRI data without a priori definition of a seed area.
The resolution says Congress "expects the cooperation of all news media organizations in protecting the lives of Americans and the capability of the government to identify, disrupt and capture terrorists by not disclosing classified intelligence programs".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com