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The findings also were surprising because earlier studies had not identified diabetes as a complication of the procedure, said Dr. Amy Krambeck, a co-author of the study.
One short-term study found a higher risk for hypertension but two did not, she said, and no study identified diabetes as a long-term risk.
These data confirmed a massive study conducted earlier by the Cancer Prevention Study II of 1.2 million US men and women that identified diabetes as an independent predictor of mortality from cancer of the colon, pancreas, breast, liver, and bladder[48].
Approximately 10% of patients had identified diabetes.
The primary automated database case definition essentially identified diabetes treated with pharmacotherapy.
30% identified diabetes mellitus as a modifiable risk factor of CASHD.
Similar(26)
Thus, the novel tissue-specific wCCS-based analysis of the 62 miRNAs altered in human diabetic muscle correctly identified diabetes-related disease mechanisms, providing support for this new method of functional annotation of in vivo global miRNA data sets.
Different workers have identified diabetes-associated genes that are also involved in antigen-processing pathways [8], [34].
Supplementary Table 1 lists the 10 previously identified diabetes-associated test antigens and two positive and two negative controls.
As an example, efficacy of transfection and silencing in human islets has been confirmed using the recently identified diabetes-linked zinc transporter ZnT8.
Newly identified diabetes-associated loci are being discovered and may open new vistas for elucidating the underlying pathophysiology of this complex disease.
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