The first round of data requests, primarily via e-mail, to acquire many of the identified datasets showed significant potential.
We searched publicly available microarray data to identify datasets with an induction of SIRT3 by either DR or fasting and then computationally identified transcription factor binding motifs enriched in the regulatory regions of SIRT3 and co-induced genes.
Using a de-identified dataset of geo-tagged mobile Internet search logs, we mined text and location patterns that are predictors of healthcare resource utilization and built statistical models that predict the probability of a user's future visit to a medical facility.
We identified a dataset of measured solubility from which we extracted about 37 thousand substances [6].
Our 2710 clusters significantly overlap with clusters obtained from previously reported piRNA datasets, containing 92 % of the 626 3' UTR piRNA-producing genes identified in the dataset of Robine et al. [ 16], and 47 % of 1957 identified in the data of Gan et al. [ 17]. 401 genes were shared by the three datasets, while our dataset contributed an additional 1600 genes.
To assess the significance of the number of genomic clusters identified in our dataset of differentially expressed genes, we employed a simulation strategy.
From the many DG sequences identified, a curated dataset of 58 sequences from species representative of the major phyla and classes was used for further phylogenetic analyses.
After the filtering steps, a total of 29,973 variants were identified in the dataset, of which 10,704 were known coding variants (Table 2).
The consistency score of G4 was the highest (score = 0.48) among 30 stable gene subsets (G2, G3,, G31) identified in the dataset of Shipp et al [ 24].
However a tag matching the 3'UTR of EP2 was identified in the dataset of unaligned tags and was expressed at extremely high level in procyclic forms, up-regulated 250-fold.
We identified a final dataset of 470 zebrafish TFRs ≥ 10 kb and 4,891 TFRs ≥ 5 kb, intermediate between the 396 opossum and 856 human TFRs ≥ 10 kb (Table 1 and Additional Files 1, 2, 3, 4).
