While a third of all PTB-containing proteins identified contain a single copy of the domain, the remaining two-thirds feature a PTB domain occurring in combination with other modular domains such as SH2, SH3, PDZ or SAM [ 85].
It is important to acknowledge from the outset that none of the studies we identified contained a quantitative assessment of tag-related mechanisms nor did they report data that would allow for a retrospective analysis.
With the exception of P40, all other antigens identified contained a canonical secretory signal sequence.
Four CPGs of receptor-type adenylate cyclase genes (ACs) were identified, containing a total of 29 genes.
Using a computational approach, the antitubulin compound was structurally dissected and analogs were identified containing a 20-fold higher antitubulin activity.
From these, 2681 ortholog sets were identified containing a gene from each genome.
All of the −2 exons identified contain a canonical splice donor site, with exon −2d also containing a splice acceptor site.
The major di-RL congeners they identified contained a C14-C14 mother; other minor congeners containing C12-C14, C14-C16, C16-C14, and C16-C14 moieties were also identified (structures 52, 50, 51, 53, and 54 in Table 1).
In addition, the Fugu proteins we identified contain a lysine-rich region immediately N-terminal to the HMG-box (Fig. 4), similar to the putative NLS sequence previously identified (Fig. 2B).
