Sentence examples for identified conformational changes from inspiring English sources

In our study we applied aMD simulations to the membrane protein for the first time to compare the dynamics of the β2AR bound to biased agonists and identified conformational changes that lead to activation of distinct signaling pathways in GPCRs.

Fitting of the gp18M atomic model into existing EM maps allowed localisation of the individual protein subunits within the tail sheath and also identified conformational changes during tail contraction (central panel in Figure 1).

By means of this approach we identify conformational changes of S5 as an essential step for the gating of CNGA1 channels, similarly to what is likely to occur in K+ channels gated by intracellular ions such as Ca2+ and Na+ 3,4.

The crystal structure of the heme-binding PAS domain in the ferric, ligand-free form, in comparison to the previously determined cyanide-bound state, identifies conformational changes induced by ligand binding that are likely essential for the signaling mechanism.

A difference distance matrix program was used to identify conformational changes in the backbone of the protein structure (49, 50).

The difference Fo − Fc Fourier map was also used to identify conformational changes of residues in the putrescine binding site as well as the active site.

However, Δ D/Δ f plots can be used to identify conformational changes of the adhered layer.[ 28] Figure 1 c and d show the Δ D/Δ f analysis for integrin liposomes and pure liposomes on uncoated SiO2 sensors.

In particular, the analysis identifies conformational changes in both RF1 and RF3 induced by their mutual presence on the ribosome, and also identifies points of contact with the ribosome and between RF1 and RF3, as well as how these contacts change through the cycle.

Therefore, alternative techniques such as Cryo-Electron Microscopy (cryo-EM), Small Angle X-ray Scattering (SAXS) and Fluorescence Resonance Energy Transfer (FRET) experiments are often used to identify conformational changes of molecules and are becoming a primary tool to obtain information about the dynamics of biological systems.

Identifying conformational changes that occur during the Pgp drug transport cycle, and understanding the molecular details of the drug/inhibitor binding sites will provide information that is necessary for structure-based design of novel Pgp inhibitors that could then be evaluated for clinical efficacy [ 10].

We compared the overall structure of MphH with MphA (5IGI45) and MphB (from ref. 45, 5IGV) to identify possible conformational changes associated with macrolide binding.