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Interestingly, it was found that the maximal sample size increase across the identified confirmatory clinical trials was less than 2-fold the originally planned sample size.
We identified confirmatory evidence supporting an eQTL within intron 19 of CLEC16A for DEXI expression within the supplementary information of two further, recent independent data sets (18, 19).
Univariable analyses were conducted using logistic regression, and any previously identified (confirmatory) predictor variables associated with Tourette syndrome or Tourette syndrome/chronic tic disorder at P<0.05 were noted.
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For example, a randomized trial of just 100 patients could lead to the termination of development of 90% of inactive agents whereas at least 80% of agents with a meaningful and realistic increase in progression-free survival would be identified for confirmatory study.
The total number of presumptive events identified for confirmatory review across all sites was 765.
Only 19% of the respondents identified the confirmatory test as western blot as seen on table 2. The respondents demonstrated knowledge of strategies for prevention of HIV as they agreed on the use of antiretroviral drugs (60%), exclusive formula feeding (58.7%), voluntary counselling and testing (58.7%), caesarean section option (52.3%).
The mecC has only ~70% similarity with mecA and is not identified with conventional confirmatory methods [ 6].
We assigned fitness scores to each of the ∼4,300 genes in E. coli, and through follow-up confirmatory studies identified 9 novel genetic targets (12 genes total) that increase E. coli ethanol tolerance (up to 6-fold improved growth).
In addition, repeat confirmatory testing identified two HIV-infected persons whose initial Western blot results were negative.
In addition, the Harvard and Cincinnati groups both reported a high false-positive rate (∼70%) among identified variants, thus requiring confirmatory sequencing which is time-consuming and adds cost [27].
Once pH1N1 was identified in a PICT, confirmatory testing in overseas laboratories was no longer considered a priority for those PICTs without laboratories, thus underestimating the number of confirmed cases in these countries.
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