Exact(12)
Moreover, we identified CHIP (Carboxy terminus of Hsp70-Interacting Protein) as the E3 ligase that ubiquitinated HIF-1α in the presence of MGO.
Moreover, we have identified CHIP as the ubiquitin ligase that promotes proteasomal degradation of HIF-1α in the presence of MGO.
Interestingly we also identified CHIP homologs in P. berghei, P. chabaudi, P. vivax and P. yoelii (respectively PB001535.02.0, PY001397.01.0, Pv087910, PY00139) whereas no homolog was found in yeast Cryptosporidium spp. and T. gondii.
We identified CHIP (Carboxyl terminus of the Hsc70-Interacting Protein) as the ubiquitin ligase that targets HIF-1α for degradation in the presence of MGO, by a mechanism that requires prior recruitment of the molecular chaperones Hsp40 and Hsp70.
Because we identified CHIP interactions with both N-terminal and C-terminal portions of LRRK2 (Figure 2), we sought to determine whether one or both of these interactions are responsible for destabilization of LRRK2 by CHIP.
Our study identified CHIP as an E3 ligase for EndoG.
Similar(48)
These investigators compared identified ChIP-seq-binding sites with falsely predicted motifs of the studied TFs.
We then identified ChiP-Seq peaks of TFs located within these predicted miRNA promoters (for the TFs included in IRGCs).
Of the 66 additional ChIP-chip peaks, 50% (33/66) overlapped with the previously identified ChIP-seq peaks, 65% (43/66) overlapped with 38 RefSeq Genes.
Unliganded ERα bound to previously identified ChIP-seq region in FAS gene in MCF-7p cells, which was reduced upon E2 treatment.
In this work, we provide evidence for negative selection acting on the identified ChIP-seq-binding sites of c-Jun (bind 1), Jun-D, and CEBPb.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com