Sentence examples for identified by methylation from inspiring English sources
Lineage commitment to particular cell types can be identified by methylation status at specific loci (2– 4).
In patients with PHP1b, epigenetic defects can be identified by methylation analysis of DMRs in the GNAS locus [Izzi et al., 2012].
Therefore, each candidate tumor suppressor gene identified by methylation screening methods has to be carefully evaluated for its role in tumor development and progression.
Examination of two genes identified by methylation profiling, NIBAN and CHAC1, revealed their biological functions in distinct processes of the ER stress response.
Interestingly, the three top CpG sites identified by methylation array to be significantly hypomethylated in KDM5C mutations cases are within promoters of genes involved in ubiquitin-mediated protein degradation [ 40- 43].
These sites can then be identified by methylation-sensitive restriction endonuclease mapping.
Interestingly, conflicting results were provided by a previous study of RKIP promoter methylation in CRC: In 28 selected cases with loss of RKIP, no methylation of the promoter region of RKIP could be identified by methylation-specific PCR independent of MMR status (Minoo et al, 2007).
Moreover, to ensure the reliability of testis and epididymis-specific methylated promoters identified by promoter methylation profile, we excluded some factors influencing the methylation profile of cfsDNA and kept the control subjects and vasectomized donors as matched as possible.
In this study, BSP was utilized to determine the methylation status at single CpG resolution of DMRs identified by genomic methylation profiling; MSP was performed for qualitative methylation screening in a small set of PC samples.
The marker candidates were selected from the literature or identified by differential methylation hybridization (DMH) technology, a method for genome-wide discovery of methylation biomarkers [ 13].
Imprinted genes such as U2af-rs1 [64], [64], Grf1 [17], Gnas [65], and Nesp [66] were identified by differential methylation analyses.
