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A specific analysis of the mouse STAT3 regulatory network identified by Ingenuity Pathway Analysis (IPA) revealed six common transcripts induced by both EphB1 and IL-6.
Prominently, arginine metabolism, which can support tissue repair and proliferation28, was identified by ingenuity pathway analysis (IPA) of metabolite content, with higher ornithine and subsequently spermidine and proline in c-Kit+ neutrophils.
Table 2 lists the top 3 (out of 69) high level functions that were identified by Ingenuity Pathways Analysis as being significantly overrepresented by differentially expressed genes in this dataset.
Furthermore, this empirical gene cluster was separately identified by Ingenuity as the predominant sub-network of the integrated transcriptome, with an overall signaling prioritization related to "Cardiovascular Development" (Figure 5A).
These included genes involved in cholesterol and steroid hormone metabolism as well as genes implicated in nervous system development that were enriched within the top biological functions identified by Ingenuity Pathway Analysis (Table 2).
We identified stratifin in our experiments through its relationship with genes focussed in the ras/Mapk pathway identified by Ingenuity Pathway Analysis (Figure 8), and we subsequently confirmed its hypermethylated status and loss of expression in 468LN cells (Figure 9, 10A).
Similar(28)
Furthermore, IL8 was found to be involved in all pathways identified by the Ingenuity resource.
The genes identified by the Ingenuity pathway analysis were enterer into the Kyoto Encyclopedia of Genes and Genomes (KEGG) database.
Finally, the signalling pathways identified by the Ingenuity analysis of our gene set were also relevant to those 6 functions (Table 5).
These are graphical descriptions of literature associations identified by the Ingenuity knowledge database, in which gene products are linked if some kind of experimentally measured association has been reported.
Upstream regulators identified by QIAGEN's Ingenuity® Pathway Analysis.
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