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Twenty-one candidate variables were identified based on previous literature and a conceptual model that is not thoroughly described in the paper.
Five different types of functional requests for children were identified based on previous work.
Fourteen OsWOX genes and fifteen AtWOX genes were identified based on previous studies (Dai et al.[2007]; Haecker et al.[2004] Nardmann et al.[2007] Vandenbussche et al.[2009]Zhang et al.[2010]) and BLAST results in this study.
Another concern is that the above studies could be confounded by discovery bias, in other words these disease genes were identified based on previous knowledge.
Two women were first identified based on previous local contacts and their involvement in community activities.
ST36 located at the anterior tibia muscle near knees were identified based on previous studies [ 13, 14].
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For these clinical anchors, it will be necessary to identify, based on previous research or clinical consensus, what a small and clinically meaningful effect may be, based on these measures.
Boundaries of the NbM complex were identified based on a previous three-dimensional reconstruction comprising the subpopulations of Ch1, Ch2, Ch4am, Ch4al, Ch4i and Ch4p [ 9, 73].
ΔHR1 was identified based on a previous study which reported that a heart rate <99 beats min−1 after supine pedalling for 2 min (not measuring gas exchange) was a preoperative indicator of postoperative cardiac and pulmonary complications.
Secondly, targets for a sub-set of down-regulated miR (miR-15, miR-16, miR-27, miR-29, miR-34 and miR-106), of which 44 targets were identified based on our previous criteria were predicted (see Additional file 4).
In each transporter family, subgroups specific for Ni or Co were identified based on either previous reports or gene neighborhoods (i.e., if a transporter gene in a certain organism was located adjacent to genes encoding Ni-dependent enzymes, NikR or B12 biosynthesis proteins, it was considered as a predicted Ni- or Co-specific transporter).
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