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The observed numbers of deaths for ICUs identified as unusual are compared to the predicted true worst numbers of deaths under the model for usual ICU performance.
Confidence intervals controlling the false coverage-statement rate (FCR) at 5% were also constructed for the ICUs identified as unusual, [ 31].
This effect is partly compounded by the minimum 150 patient-volume requirement, and we discuss below issues of missing data and data quality with regard to the particular ICUs identified as unusual.
Factors identified as unusual to a particular carer, for example a higher level of education, were investigated in order to see if this might explain why the case study children had a satisfactory growth rate compared to other children.
In P. syringae, the HrpR and HrpS proteins show a high sequence similarity to the NtrC family of transcriptional RRs and have been previously identified as unusual EBPs lacking the N-terminal REC domain; however, similar to other EBPs, they retain the domain that interacts with the sigma-54 RNA polymerase holoenzyme plus the C-terminal DNA-binding domain [ 39- 42].
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Commonly expressed themes will be identified as well as unusual cases.
Identifying potentially unusual ICU performance: Over the period of observation, 27 ICUs were identified as potentially unusual.
However, deck rotation in straight bridges has been identified as an unusual failure mode.
CRISPRs were identified as an unusual sequence element containing a series of 29-nucleotide repeats separated with 32-nucleotide ''spacer'' sequences in Escherichia coli genome (Ishino et al. 1987; Wiedenheft et al. 2012), and function as RNA interference mechanism to bind and cleave target DNA.
In total, 80 of these 213 genes identified as exhibiting unusual compositional properties and unique to a single Neisseria strain are present in the genomes of other organisms.
By contrast, the heatwave experienced in western Europe in 2003 was immediately identified as an unusual meteorological event and shortly afterwards analyses of resultant excess mortality were available, using data from routine systems (23).
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