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The authors of the deep sequencing analysis identified as many as 71 snoRNAs up-regulated (more than twofold) in higher stage PCa, but they subsequently focused only on the prognostic role of miRNA signatures.
In the present study, 40 differentially regulated genes were identified at twofold change and P < 0.05.
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Figure 5a outlines how each comparison was performed and the number of genes identified as at least twofold up and downregulated in each pairwise comparison.
The behaviors of the gene products identified as at least twofold up/down-regulated were grouped into three sets using k-means clustering and named according to the time of their induction during the 48-hour time course following the initiation of blood feeding.
Seventeen genes were identified as IL-10-inducible (> twofold increase in gene expression) in both patients with RA, although a total of 87 gene signals were increased by IL-10 in either patient.
This hemoglobin, which was identified as HbA1c, was found to be increased twofold in patients with diabetes compared with healthy individuals (17).
Expression of Lgr5 (5.2-fold) as well as several genes previously identified as stem cell-specific were enriched more than twofold in GFPhigh populations (24 among Ki67+ and 19 among Ki67−) compared to GFPlow.
This phenotype is a plausible consequence of the approximately twofold increase in expression of PER2, which we identified as the main miRNA-regulated core clock component in hepatocytes.
This analysis identified as potential AR-binding sites 1,532 promoter regions that were more than twofold enriched in androgen-stimulated cells compared with vehicle-treated cells (Fig 1A; see supplementary Table 1 and supplementary information online).
In the present study, microRNAs that changed at least twofold and differed markedly (P < 0.05) between the two cell models were identified as potentially interesting.
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