Using this regulation model, already well known TFs were identified as substantial regulators, but, for DCT, also the less prominent regulator SOX5 was found.
Curbs and steps were identified as substantial barriers to ascend independently and daunting to descend due to the risk of a forward tip.
However, by the early 1990s, infectious diseases were again being identified as substantial domestic and international public health threats in and to western nations (4 ).
In a prospective observational study of 2,200 critically ill patients, mechanical ventilation > 48 hours and coagulopathy were identified as substantial risk factors for clinically significant bleeding (odds ratios 15.6 and 4.3, respectively) [ 4].
Thermophiles have been previously identified as substantial exchangers of genes to the point where some thermophiles such as Aquifex aeolicus and Thermotoga maritima appear to be hybrids comprising significant numbers of genes from lineages as diverse as the Epsilon-proteobacteria, thermophilic Clostridia, and the Archaea [ 16, 85, 97].
In a recent review of standard methods for evaluating exposure/hazards, disease mapping and clustering techniques, Bayesian approaches, Markov Chain Monte Carlo (MCMC) and geostatistical methods, Mather et al. [ 6] identified as substantial weaknesses (1) the lack of temporal referencing of geospatial data and (2) the inability of methods to account for residential histories.
In CMS, the systems that have been identified as requiring substantial upgrades are the Tracker and the Level 1 trigger.
Limited standardisation in defining injuries has repeatedly been reported as a serious methodological pitfall when comparing study outcomes [ 13, 31] and has been identified as a substantial methodological challenge for future studies [ 32].
Since then food intake for Indigenous peoples has been further compounded by many factors [ 8] including inadequate food access and availability [ 3, 10], food insecurity [ 11] and financial stress [ 12], the last identified as a substantial barrier to a healthy diet [ 13, 14].
For unstable patients, the costs of hospital treatment were identified as being a substantial cost area.
