Exact(4)
Six and 4 targets were identified as over or under expressed at 50 PSU, respectively, and greatest fold differences between treatments occurred for beta-tubulin, 40S ribosomal protein, and phosphoethanolamine N-methyltransferase (PhNMT) genes.
However, in the current format, these criteria should only be applied to individuals already identified as over 40 years in order to refine the age ranges used for advanced age.
Another gene related to AML is ANGPT1, that encodes protein angiopoietin 1. Angiopoietins are proteins with important roles in vascular development and angiogenesis which have also been identified as over expressed in bone marrow of AML patients [ 24].
Both of the two cuticular pre-cursor genes, identified as over expressed in the Akron strain also showed elevated expression (2.6- and 2.5-fold respectively) and a peroxiredoxin, belonging to the typical 2-cysteine cytosolic group [ 25], TPX2 was over expressed 4.8-fold.
Similar(56)
A number of proteins were identified as over-expressed in cancers and they may be valuable for future diagnosis and prognosis.
With 2DE combined with MS platform, transglutaminase 3 (TGM3), heat shock protein 70 (Hsp70), TPM4-ALK fusion oncoprotein 2, myosin light polypeptide 6, keratin I and calreticulin were identified as over-expressed in tumor tissues [120, 131].
No COG functional category was identified as over-represented in the HGT sequences as compared to the genome of wBm (Fisher's Exact test, Bonferroni step-down correction, p<0.01).
Almost all genes in the glycolytic pathway that converts glucose into pyruvate were identified as over-expressed in type 2B fibers while many genes of oxidative phosphorylation and fatty acids oxidation were over-expressed in type 1 fibers (Table 3).
A total of 55 canonical pathways were identified as over-represented due to this differential expression.
The KEGG pathway 'Glycolysis/gluconeogeneis' was not identified as over-represented.
After adjustment for multiple testing, ETF, Elk-1 and NF-Y were identified as over-represented.
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