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Using this approach, 132 (9.3%) subjects were identified as high dose users (standardized one year prevalence: 9.6%).
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But therapeutic intervention for people identified as high risk has been limited because many systemic treatments are barred from clinical use due to the severe side effects they produce when used at the high doses required to achieve a therapeutic response.
Dose level 4 was identified as the highest administered dose and hence DL 3, as discussed above, was expanded to a total sample of 15 patients.
Dose level 3 was thus identified as the highest administered dose.
Logistic regression was performed to identify associations with high dose opioid prescription defined as ≥ 120 ME/day [Franklin et al., 2012].
Granulocytopenia was consistently identified as a dose-limiting toxicity (DLT).
Dose level 3 was identified as the highest administered DL.
Consequently, in phase II trials, physicians often choose only two or three doses as an initial step to identify a potential lower dose that is sufficiently active and equally effective as higher doses.
Methylprednisolone therapy seems as effective as high-dose prednisone in patients with relapse of SLE nephritis.
It has been observed that there is no significant difference on applying higher doses of vermicompost and lowest dose (5 t/ha) is as effective as higher doses.
To identify the MaxED, one approach is to use a frequentist multiple hypothesis testing procedure, in the spirit of Strassburger et al. [ 13], to evaluate whether one or more doses are sufficiently active and in cases where multiple doses are active, whether lower doses are equally effective as higher doses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com