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Reactive oxygen species, DNA crosslinking agents, and aldehydes have been identified as endogenous and exogenous sources of DNA damage which, if un- or misrepaired, contributes to carcinogenesis.
A major category of the natural angiogenic inhibitor is the serine proteinase inhibitor (SERPIN) family, as a number of serpin members (e.g. PEDF, SERPINA3K, maspin, α1-antitrypsin, anti-thrombin) have been identified as endogenous angiogenic inhibitors [11] [15].
BAs were identified as endogenous FXR ligands with high affinity.
Those constructs identified as endogenous are affected by exogenous and other endogenous variables in the model [ 50].
Shortly thereafter, oxysterols as well as cholesterol metabolites were identified as endogenous activators of LXRs, thus LXRs were "deorphanized" [ 60].
The set of alignment parameters has shown a significant impact on the population of sequencing reads identified as endogenous by BWA.
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Notably, Hnf4α (hepatocyte nuclear factor 4 alpha), a member of the steroid/thyroid hormone receptor superfamily is a transcriptional activator [62] whose ligand has been identified as tightly bound endogenous fatty acids [63].
While it has been more than 20 years since NO was identified as an endogenous agent produced by the cardiovascular system, until recently attempts to create acceptable therapeutic measures for the modulation of endogenous NO activity or production have not progressed much.
It is involved in the inflammatory response, and is identified as an endogenous pyrogen.
Ghrelin is a gastric acyl-peptide that has been identified as an endogenous ligand for the growth hormone secretagogue receptor.
Nociceptin/orphanin FQ (N/OFQ) was recently identified as the endogenous ligand for the opioid-receptor like (ORL1) receptor.
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