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If we use the 4D dataset as a control, 42.9% of the 12mers in the 2D dataset can be identified as constrained by SiPhy.
In particular, using the 4D sites as a control, only 16.1% of all 12mers in the 2D dataset can be identified as constrained, almost a 3-fold decrease in predictive power compared to the 42.9% called by the π-based method.
Those identified as "constrained" talked with family members and made preparations for an earthquake.
Similar(57)
Many barriers were also identified as constraining the adoption of the forthcoming change at the actors, values and methods levels in the educational and professional systems.
Furthermore, the lysine biosynthesis pathway in Synechocystis was identified as thermodynamically constrained, impacting both endogenous and heterologous reactions through low 2-oxoglutarate levels.
"I identify as queer.
Many identify as heterosexual.
Most people identify as straight.
In accordance with our results, financial factors, lack of familiarity with the patient, bed availability, and lack of time have been identified as factors that constrain patient-centered performance [ 44, 48].
Beauvoir would have appreciated the fact that her current philosophical status reflects our changed understanding of the domain of philosophy and the changed situation of women, for it confirms her idea of situated freedom that our capacity for agency and meaning-making, that whether or not we are identified as agents and meaning-makers, is constrained, though never determined, by our situation.
Using bootstrapped sequences as a control and controlling FDR at 5%, PhastCons identified 6.5% of the bases as constrained, whereas GERP called 5.6% as constrained, both of which are lower than the 10.2% identified by SiPhy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com