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"It was identified as a localized failure in 2007," Mr. Seaton said.
DOI: http://dx.doi.org/10.7554/eLife.04158.007 We also examined the distribution of the mRNA encoding β-thymosin, which we had previously identified as a localized mRNA in Aplysia SNs (Moccia et al., 2003).
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PARP1 was long thought to be the only enzyme with poly(ADP-ribosyl)ation activity until two PARP isoforms were identified in plants [ 18] and, simultaneously, tankyrase was identified as a PARP localized at the telomere in humans [ 19].
Recently, fat specific protein 27 (FSP27 or Cidec) was identified as a protein which localizes on the surface of lipid droplets in white adipocytes and contributes to energy storage by promoting the formation of unilocular lipid droplets [10], [11].
Tau has historically been identified as a microtubule-associated protein localized to the axon of mature neurons [ 20, 21], and a prerequisite for trans-synaptic propagation would be the localization of tau specifically at the synapse.
The gene was originally identified as being localized in a genomic region linked to breast cancer and subsequent studies on melanoma cell lines revealed point mutations in the TTC4 protein that may be associated with the progression of malignant melanoma.
The fragile histidine triad (FHIT) gene has been identified as a candidate tumour suppressor gene localized in FRA3B, the most sensitive common fragile site, at chromosome 3p14.2 (Ohta et al, 1996).
Localization of EhCP-A5 demonstrated in this study does not support the inference by the previous study (Jacobs et al., 1998), in which EhCP-A5 was identified as a membrane-binding protein and localized to the plasma membrane by transmission electron microscopy using an antibody raised against 12-a.a.-long peptide specific to EhCP-A5.
As stated above, VMD2 was originally identified as being localized to RPE cells.
Mutations in VMD2 have been implicated in Best vitelliform macular dystrophy and AMD, and bestrophin was originally identified as being localized to the basolateral plasma membrane of retinal pigment epithelium (RPE) cells [5].
For example, several factors have been identified as controlling localized gene transcription [ 31].
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