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For example we studied the regulation of MAP kinase by protein kinase C and at the onset of meiosis, and identified and structurally characterized a novel effector of the Ras oncoprotein, the Ral guanine nucleotide dissociation stimulator.
In this study, glycan-charged dolichol phosphate from the hyperthermophile Pyrococcus furiosus was identified and structurally characterized.
A total of 39 triterpenoid compounds had been identified and structurally elucidated from A. cinnamomea based on the review of Geethangili and Tzeng (2011).
In summary, we have identified and structurally characterized an interaction between STIL and PLK4, two key centriole duplication factors.
Four barley PcG gene homologues, named HvFIE, HvE Z), HvSu z 12a, and HvSu z 12b were identified and structurally and phylogenetically characterized.
More recently, PAL have also been identified and structurally characterized in two Cyanobacteria belonging to the order Nostocales, where they are involved in a pathway whose end product is yet unknown [ 18].
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We identify and structurally characterize an one-ring closed intermediate induced by ATP hydrolysis wherein the closed TRiC ring exhibits an observable chamber expansion.
For the first time we identify and structurally and chemically characterise precipitates of a non-equilibrium ZnxAl1−x (x≥0.7) transition phase and show that these precipitates dissolve during deformation at 85 °C.
To demonstrate that this approach has the potential of producing novel two-hit inhibitors of the folate pathway, we identify and structurally characterize a fragment-like molecule that simultaneously engages both active sites.
This blocked complex has been exploited successfully as a target for structure-based discovery of a new inhibitor of Arf activation [8], highlighting the interest of identifying and structurally characterizing reaction intermediates in drug design.
Ub-based suicide inhibitors have been useful reagents to identify and structurally characterize DUBs, but so far were considered as DUB specific.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com