If a method of identifying patients who have a high risk of local failure could be identified, a dose-escalation regimen that allows a higher rate of treatment-associated toxicity may be seen as worthwhile.
Identify an escalation path if something goes wrong.
With dose escalation up to 4 mg/m/day × 3 days per cycle, we identified an MTD of 3.0 mg/m/day.
Results presented here identify a much earlier escalation in violence in the poorest communities and a peak at a much higher level.
Results: We identified 5 RR escalation patterns among 918 CRI positive patients (Fig. 116).
Another problem raised by the legislators, who spoke on condition they not be identified, concerned escalations or changes in covert actions about which they were previously notified.
Antimicrobial stewards identified de-escalation, no meaningful change in therapy, or escalation in 53, 41, and 6% of vignettes reviewed whereas, the spectrum score method with credits identified de-escalation, no meaningful change in therapy, or escalation by day 4 of therapy in 54, 42, and 4 of these vignettes, respectively.
Teaching a student to identify this escalation is essential if she's to learn how to catch herself on the way up.
The study consisted of two phases, a dose escalation phase meant to identify a RPTD and a biomarker expanded cohort at the RPTD, which was meant to better describe the effect of this regimen on several markers of angiogenesis.
We aimed to describe the prognosis of cirrhotic patients admitted to a general ICU, to assess the predictors of mortality in this population, and, finally, to identify a subgroup of patients in whom intensive care escalation might be discussed.
Analysis from the Placements Northwest census identifies sharp escalation in costs, for example a £45m increase in expenditure on residential care placements this year.
