Sentence examples for identified alteration from inspiring English sources

The mutation c.3700_3704del5 found in four families was the second most commonly identified alteration, which contributed to 11.4% of mutations detected in BRCA1.

We have also identified alteration of the genes that were previously described in association with hypoxia (Additional file 2: Table S1, "Hypoxia").

These observations are intriguing given the high frequency of AKT signalling pathway activation in HGSC [ 77- 79], whereby the TCGA study identified alteration in the PI3K/AKT and RAS pathways in approximately 45% of HGSC [ 11].

Among the identified alteration in biological activities in OTSCC, the most significantly enhanced are related to the extracellular matrix remodeling (GO 0030574, GO 0030198), I-kappaB kinase/NF-kappaB cascade (GO 0043123) and chemotaxis (GO 0050921), which are known to be related to tumorgenesis and progression of the cancer.

Mapping altered metabolites to KEGG and SMPDB pathways identified alterations in immunomodulatory pathways including tryptophan catabolism and eicosanoid biosynthesis.

Prenatal imaging has identified alterations of brain growth in fetuses with congenital heart disease.

Recently identified alterations in the function of specific genes in these cancers provide new potential therapeutic targets.

Given this landscape, an imminent challenge is to determine how best to interpret cancer genomic data, including which of the identified alterations promote the initiation or progression of cancer10,12.

We identified alterations in DNA copy number and complex genomic rearrangements and demonstrated a low somatic point mutation frequency in the absence of tobacco mutagens.

In the current study, we identified alterations in both systemic and cerebral hemodynamics.

CONCLUSIONS AND IMPLICATIONS These studies identified alterations in taurine/hypotaurine metabolism in the hearts and skeletal muscles of mice treated with sorafenib.