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None of the studies identified adverse effects of telephone follow-up.
Previous research has identified adverse effects of falling and knee OA across different dimensions of HRQoL, including mental health.
Some adverse effects (e.g. ischaemic bowel) remain under recognized, while newly identified adverse effects continue to be described in the literature.
Although privacy impact assessments of the UK's TUO, have not identified adverse effects [ 45], a similar 'one-stop-shop' portal that links personal information, not including death notifications, across government departments in Australia has not been without security concerns [ 46].
Some authors have identified adverse effects associated with high dosages of dietary polyphenols in the gastrointestinal environment, including caecal and colonic fermentation processes [ 8], but well-documented experiments addressing the in vivo effects of dietary blackcurrant polyphenols are scarce [ 3].
We identified adverse effects in the reproductive tract in all BPA-treated groups, but it is interesting that the lowest dose (BPA-0.1) was the most affected (Table 3).
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Drugs too often turn out to have more serious dangers than previously understood, and incentives for monitoring new drugs and identifying adverse effects that emerge after a drug is approved are critical.
Included is a discussion of the multigenerational tests designed to determine reproductive and developmental effects, as well as protocols specific for identifying adverse effects in the developing organism.
Additionally, findings of the ADME study have been used rarely to understand adverse effects observed in other short- and long-term studies in the current hazard-based testing relying mostly on identifying adverse effects, often at very high dose levels.
Modified early life-stage tests were carried out with zebrafish exposed to the known thyroid inhibitor potassium perchlorate (0, 62.5, 125, 250, 500 and 5000 μg/L) to identify adverse effects on the hypothalamic-pituitary thyroid axis.
Case-control studies can be very successful in identifying adverse effects from a new treatment where the risk is large, and the adverse effect being studied is otherwise rare in the group being treated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com