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Network radiality rules are employed to assess if a particular search path has identified a switch that can be closed or if the path is worth pursuing further.
Many studies have identified a switch from fatty acid oxidation towards a reliance on glucose metabolism for energy generation in the hypertrophied and failing heart.
For example, recent reports identified a switch between adipogenesis and osteogenesis that can be epigenetically regulated by EZH2 (Chen et al, 2011; Wang et al, 2010), and suppression of the methyltransferase activity via phosphorylation of EZH2 at Thr 487 by cyclin-dependent kinase 1 (CDK1) results in hMSC differentiation into osteoblasts (Wei et al, 2011).
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These results identify a switch in the molecular and functional properties of glutamate receptors operated by alternative splicing.
Such hybrid techniques need to identify a switching point which is conventionally found through expensive trial-and-error and exhaustive search routines.
Scientists have identified a molecular "switch" in blood samples that increases a woman's chances of having breast cancer.
Using state-of-the-art DNA editing tools, they have identified a genetic switch that helps govern the body's metabolism.
We have identified a genetic switch (MED13) in the heart that increases whole-body metabolism.
Significantly, we then identified a temporal switch that healthy animals undergo from a proinflammatory gene expression profile to a regenerative and proliferation profile [ 22].
This experiment identified a strong epigenetic switch at the Cyp2b10 TSS region, from a repressive (H3K27me3 rich) to an active (H3K4me2, H3K9ac rich, H3K27me3 poor) chromatin configuration following 4 weeks of PB treatment (Figures 4A and 4B).
We identified a novel, bimodal switch of p53 dynamics modulated by DNA-damage strength that is crucial for cell-fate control.
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