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The present array CGH analysis identified a possible target gene IFNG from AMP2 (Rp11-298M11; p = 0.0000001), which is physically mapped close to the HDM2 oncogene locus[ 24].
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In this work, we developed an in-silico target fishing procedure to identify a possible target for this class of compounds based on shape similarity, inverse docking procedure and consensus score rank-by-rank.
In this way, we identify a possible target for future pharmacological interventions designed to suppress drug seeking.
To determine consequences of gene amplification and to identify a possible target gene of the amplicon we performed real time RT-PCR.
These data also identify a possible target for the treatment of tomaculous neuropathies.
To identify a possible target for MAG-Fc's effect on MN survival, double immunofluorescence studies were performed on sciatic nerve sections.
A similarity search against 3'UTR sequences of the human genome allowed us to identify a possible target for this predicted mature sequence, PLEKHA6 (pleckstrin homology domain containing, family A member 6) (Fig. 7).
This study also helps to identify a possible target population of professionals for any future R&D strategy, thus increasing the likelihood of any such R&D strategy achieving enduring success.
Identify a possible target and temporarily blind him by flashing your light at their eyes in order to disorient them.
Using an animal model of autism, EU-AIMS has already identified a possible drug target on synapses – the connections between nerve cells – where a particular brain receptor was found to be produced in excess.
MMP-2 has, for example, been identified as a possible target in cardiovascular disease, since it was identified as the protease responsible for degradation of the vasodilator peptide andrenomedullin, with one of the resulting fragment peptides having vasoconstrictive properties, possibly leading to hypertension (Martinez et al. 2004).
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