Probably the three-month ophthalmological evaluation was too early to identify a modification.
Recently, Wang et al. (2008) identified a histone modification module consisting of a combination of 17 modifications that are overrepresented at the promoters of genes that tend to be highly expressed in human CD4+ T cells (38).
We identified a specific modification pattern, termed "bivalent domains," consisting of large regions of H3 lysine 27 methylation harboring smaller regions of H3 lysine 4 methylation.
Using big-PI predictor for GPI modification site prediction, we identified a potential GPI modification site at the C-terminus of SOCS6 at Asn. Mutagenesis was performed to generate a SOCS6-N524L mutallelelele.
Here, we identified a novel protein modification mechanism that may answer the above questions.
In our current study we have identified a novel posttranslational modification of BRCA1, namely methylation.
Through acute deletion of Mll1, we identified a histone H4 modification that was rapidly and synchronously reduced as the expression of MLL1 target genes ceased.
Trichomonas vaginalis was identified using a modification of the Amplicor assay that included primers and probes specific to T. vaginalis DNA [7].
If statistically significant and metrically relevant DIF is identified, then a modification or a substitution of this item should be performed, with subsequent testing of equivalence with the original.
Attempts to identify a specific modification that can convert MyoD1 from an inactive to an active form have not succeeded.
