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As expected, the appetitive reward task identified a main effect of task in a set of regions previously associated with primary and monetary rewards [31], [32], [33], [34], [35], [36], including the medial ventral and orbital prefrontal cortices, the ventral striatum, and the posterior cingulate cortex (Figure 2).
An analysis of the WM measures from the Wechsler scales identified a main effect of group on WM performance on the LNS test (F 2,45) = 4.32, p = 0.02, ηp2 = 0.13) (see Table 4 for means and SEs).
For the study of diazinon, dieldrin, and Ni2+ conducted in differentiating cells, global ANOVA (factors of treatment, gene, time) identified a main effect of treatment (p < 0.0001) and interactions of treatment × time (p < 0.02), treatment × gene (p < 0.0001), and treatment × time × gene (p < 0.0001).
In the current study, we identified a main effect of pubertal status on MD in a diverse set of white matter regions, in which MD was reduced in male adolescents with more advanced pubertal development compared to their less well-developed peers.
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In both BA44 and BA45 of the left hemisphere, an interaction between the effect of Agent and of Rating was identified, with a main effect of rating in BA45 corresponding to increased response when attention was explicitly directed towards the emotion.
Additionally, to check for structural changes between each period (pre versus post, pre versus followup, and post versus followup), paired t-tests were performed for each cluster identified as a main effect in the ANCOVA.
Interestingly, HOC1 was not identified as a main effect QTL through one-dimensional interval mapping (data not shown) and was instead only detected when considered as an interaction with HOC4, highlighting the importance of testing for epistasis to build more comprehensive models of genetic architecture.
To further investigate whether the correlation patterns identified in a main effect of memory-related region (hippocampus and PHC) were observed in the unsuccessful encoding of IWS memories (i.e., IO memories), we compared hippocampal-related correlations with PHC-related correlations in the same ROIs during IO.
Since we were interested in identifying differences between relief and reward activity in the regions identified as showing a main effect of either relief or reward, the results from the relief>reward analysis were masked by the thresholded statistical map showing significant positive relief activation.
A potential semaphorin receptor, plexin A3, was also identified as showing a main effect of treatment.
There was a very high degree of overlap between the regions identified which demonstrated a main effect of puberty, although there was a reduction in the whole brain corrected significance level of our findings from α = 0.05 to a trend level of α = 0.1.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com