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We successfully identified a lead compound with remarkable anti-HIV-1 activity (EC50 = 0.09 μM).
In a second step, we designed eight modified ACE2 cmRNA sequences and identified a lead sequence for in vivo application.
From this panel, we identified a lead mimetic that is bound by members of the PGT128 or PGT130 antibody families20 as well as their putative common gl precursor.
Previously we identified a lead sulfonamide that selectively bound to the pleckstrin homology (PH) domain of AKT and induced apoptosis when present at low micromolar concentrations.
This study has identified a lead DuoGel™ formulation that will safely deliver IQP-0528 to prevent sexual HIV-1 transmission in the vagina and rectum.
We identified a lead biodegradable polymeric vector, E6, which resulted in increased polyplex stability, DNA protection and achieved sustained high levels of transgene expression inside 3D PEG-DMA hydrogels for at least 12 days.
Similar(48)
Traditional immunization and display antibody discovery methods rely on competitive selection amongst a pool of antibodies to identify a lead.
We use this platform to determine the role of GLIS3 in human pancreatic β-cell generation and survival, and to identify a lead hit drug candidate for treating the broad range of human patients who suffer from GLIS3-associated diabetes.
The facility shall identify a lead interpreting physician who shall have the general responsibility of ensuring that the quality assurance program meets all requirements of paragraphs (d) through (f) of this section.
This multi-part case tells the story of security planning for the 1996 Olympic games in Atlanta, focusing particularly on two themes: the difficulty, in the highly-decentralized US federal system, of identifying a lead body of law enforcement officials to make key planning decisions, and the question of what sorts of threats should and can be anticipated.
A further report into human trafficking to be published this week by the Welsh Refugee Council says that "local authorities should identify a lead officer to provide support and knowledge to practitioners across the local authority on human trafficking".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com